In recent years, recent developments in molecular biology and spatial analysis methods have produced a ground-breaking method for comprehending gene expression in the context of tissue architecture. With the aid of the state-of-the-art molecular biology method known as spatial transcriptomics, it is now possible to examine gene expression patterns in relation to tissue architecture and spatial organization. Combining conventional gene expression analysis with geographical data provides a more thorough understanding of how genes are expressed and controlled tissues. Nature Methods dubbed it the “Method of the Year” because of its key impact in 2020.
Spatial transcriptomics, a method that sheds fresh information on the molecular complexities of numerous eye disorders and ailments, has emerged as a potential study area in ophthalmology. A careful examination of the patterns of gene expression across the numerous tissue layers of the eye’s complex anatomy is necessary. Spatial transcriptomics in ophthalmology research can be very helpful for comprehending the genetic and cellular mechanisms behind diverse eye disorders and ailments.