Metal-organic frameworks (MOFs) in cancer therapeutics: exploring their potential and safety profile
Soumya Prakash Biswal
Department of Applied Science, Kalinga Institute of Industrial Technology University, Odisha, India

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Metal-organic frameworks (MOFs) are crystalline materials known for their distinctive properties like high porosity, an extensive surface area, and ability to encase molecules, making them attractive candidates for cancer therapy drug delivery. Metal ions or clusters connected with organic ligands form these frameworks, creating an ideal structure for transporting and selectively releasing drugs to target sites (particularly cancer cells) while sparing healthy tissues. Recent research has investigated MOFs as potential aids for improving cancer therapies such as chemotherapy, photodynamic therapy, and early cancer detection. However, before transitioning MOFs into clinical settings, assessing their in vivo toxicity and biocompatibility is essential. Studies conducted on living organisms provide important insight into how MOFs behave within biological systems, offering valuable data regarding their safety and efficacy as drug carriers. Although MOFs offer tremendous promise, their use requires careful evaluation due to potential toxicity issues, targeting cancer cells directly, and physiological conditions stability issues that must be overcome through extensive research and clinical trials. Research being undertaken today seeks to address these challenges and optimize MOFs for clinical application - creating more effective and precise cancer therapies. As we continue to understand MOFs’ capabilities and address their limitations, these unique structures represent hope in cancer therapeutics, potentially revolutionizing treatment methodologies and improving patient outcomes in this fight against cancer.


  1. Drug deliver
  2. Cancer therapy
  3. Biocompatibility
  4. Nanomedicine